For an oocyte to be All set for fertilization and advancement into an embryo, the best set of genes should be turned on. Namekawa suspected this pre-programming on the oocyte genome happens in various phases — the initial a single starting up across the time a feminine is born. He thought that chromatin remodeling proteins did Significantly of the operate, by shifting spools all over.
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Each is made up of a mass of thread-like DNA — akin to four hundred miles of yarn. To keep it from devolving right into a tangle, the DNA is wrapped close to a number of protein spools, called nucleosomes.
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Namekawa believes that in human oocytes, adjustments in these patterns could disrupt the sensitive choreography of genes currently being turned on and off at the appropriate instances — leaving them unprepared for fertilization or expansion into healthy embryos. Adjustments in chromatin composition being an oocyte ages might also affect just how that chromosomes segregate throughout cell division.
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